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Contraindicated (1)pentobarbital will lessen the extent or impact of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is chargeable for the development and elimination of cariprazine's active metabolites.pentobarbital will lessen the level or impact of lonafarnib by affecting hepatic/intestinal enzyme CY